Immunoreactive digitalis - like in pre - eclampsia substance
نویسندگان
چکیده
An endogenous digitalis-like substance (DLS) may be involved in the pathogenesis of essential hypertension and pre-eclampsia. The digoxin levels in maternal and cord blood of 504 randomly selected patients were determined. Since none of the patients received digoxin, these levels indicated a crossreacting substance (immunoreactive DLS). DLS levels were significantly higher in the cord blood of preeclamptic patients than in the cord blood of controls. DLS levels in cord blood increased with the severity of pre-eclampsia, and levels were higher in primigravidas than in multigravidas. The structure and biological activity of DLS must be determined before definite conclusions about its role in the pathogenesis of pre-eclampsia can be made.
منابع مشابه
A New Method to Estimate Inhibition Percentage of Endogenous Digitalis in Patients with Pre-eclampsia
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Na , K -ATPase. Clin Biochem 1985; 18:48-55 16 Gruber KA, Whitaker JM, Buckalew VM. Endogenous digitalislike substance in plasma and volume-expanded dogs. Nature 1980; 287:743-45 17 Gusdon JP, Buckalew VM, Hennessy JF. A digoxin-like immunoreactive substance in preeclampsia. Am J Obstet Gynecol 1984; 150:83-85 18 Lackner TE, Valdes R. Spurious digoxin concentrations. Eur J Clin Pharmacol 1984; ...
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